INDICATION
MUSE (alprostadil) is indicated for the treatment of erectile dysfunction. Studies that established benefit demonstrated improvements in success rates for sexual intercourse compare with similarly administered placebo.
Warning: Do not drive or do other hazardous activities after taking MUSE because low blood pressure or fainting may occur. Fainting within 1 hour of taking MUSE has been reported.
Important Risk Information about MUSE
Because sex is a vigorous physical activity and increases heart rate and work, make certain that your doctor determines that you are healthy enough for sex before you use MUSE. If you have chest pain, nausea or other discomforts during sex, seek immediate medical help.
You can continue to read Important Risk Information at the bottom of this page
Patient Information
Full Prescribing Information
U.S. Consumers
U.S. Healthcare Professionals
How to use MUSE
Training video
The MUSE administration video can help you better understand how MUSE is administered.
You will need the Adobe Flash Player to view this video. If you don't have the player installed on your computer, you can download it for free.
For best results, follow these simple steps1
Below is a list of step-by-step instructions for how to use MUSE on your own.
By following these instructions, you'll get the best results: an erection within 5 to 10 minutes that may last from 30 to 60 minutes.
Keep in mind that each MUSE applicator is individually foil wrapped for convenience. The applicator contained in each foil pouch is for a single administration only.
You can also download a PDF file with this information. This printable document includes folding instructions for easy reference.
You'll need the Adobe Acrobat Reader in order to display the reference card.
If you don't have Acrobat Reader installed on your computer, you can
download it for free.
STEP 1
Urinate immediately before use, then shake the penis several times to remove excess urine. A moist urethra makes it easier to insert MUSE and will also help dissolve the medicated pellet.
STEP 2
Open the foil pouch by tearing fully across from the notched edge.
Let the applicator slide out of the package. Save the foil pouch for
discarding the applicator later.
STEP 3
Remove the protective cover from the applicator stem by holding the
body of the applicator between your thumb and forefinger. Twist the
body and pull out the applicator from the cover, but don't push the
applicator button. Save the cover for discarding the applicator later.
STEP 4
Look carefully at the applicator. It is see-through, so you should
be able to see the medicated pellet at the end of the stem. Make
sure that the medicated pellet is present before inserting MUSE.
STEP 5
Hold the applicator in the way that is most comfortable for you.
STEP 6
Review the figure shown here to become familiar with the anatomy of the penis.
Note the location of the urethra, the tube in the penis through
which men pass urine and semen, and the glans, which is the tip of the penis.
While sitting or standing (whichever is more comfortable for you), take a few seconds to gently
and slowly stretch the penis upward to its full length while gently squeezing the glans.
This straightens and opens the urethra.
While keeping the penis stretched, slowly insert the applicator stem into the urethra up to
the collar of the applicator. If you feel any discomfort or a pulling sensation, withdraw the
applicator slightly and then gently reinsert.
STEP 7
Gently and completely push down the button at the top of the applicator until it stops.
You must do this to make sure that the medicated pellet is completely released.
Hold the applicator in this position for 5 seconds.
STEP 8
Gently rock the applicator from side to side to separate the medicated pellet
from the applicator tip. If you apply too much pressure, you may scratch the
lining of the urethra and cause it to bleed.
STEP 9
Remove the applicator while keeping the penis upright.
STEP 10
Visually inspect the applicator to see that the medication is no longer in the applicator. Do not touch the stem. If you notice some residual medication in the end of the applicator, gently reinsert into the urethra and repeat steps 7, 8, and 9.
STEP 11
Extending the penis to its full length, massage the penis firmly between your hands for at least 10 seconds.
This will help you absorb the medication. If you feel a burning sensation, it may help to continue massaging
the penis for another 30-60 seconds or until the discomfort stops.
STEP 12
Remember that each applicator is good for a single administration only. Replace the cover on the applicator, place it in the opened foil pouch, fold, and discard as normal household waste.
Important note: After you have used MUSE, it is important to sit, stand, or walk for about 10 minutes while your erection develops. This will increase blood flow to the penis and improve the quality of your erection.
References
1. Muse [package insert]. Somerset, NJ: Meda Pharmaceuticals Inc; 2011.
INDICATION: MUSE (alprostadil) is indicated for the treatment of erectile dysfunction. Studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with similarly administered placebo.
Warning: Do not drive or do other hazardous activities after taking MUSE because low blood pressure or fainting may occur. Fainting within 1 hour of taking MUSE has been reported.
Important Risk Information
Because sex is a vigorous physical activity and increases heart rate and work, make certain that your doctor determines that you are healthy enough for sex before you use MUSE. If you have chest pain, nausea or other discomforts during sex, seek immediate medical help.
The first time you use MUSE should be in your doctor's office so that your doctor can find the dose that is right for you and so that you can be monitored for low blood pressure, which may cause you to faint.
Make sure your doctor knows about any drugs you are using to lower blood pressure before you start using MUSE. Tell your doctor if you have any symptoms indicating that blood pressure may be too low (e.g., lightheadedness) when you use MUSE.
Carefully follow your doctor's instructions for inserting MUSE in the urethra to avoid scratching the inside of your urethra (the channel that urine and semen pass through), which could result in minor bleeding. If you are on anti-coagulant (blood thinning) medicine, or have a bleeding disorder, you may be at higher risk of bleeding.
If you have an erection lasting more than 4 hours, seek immediate medical help to avoid long-term injury.
Use a condom if your partner is pregnant, or could become pregnant.
MUSE does not protect against sexually transmitted diseases.
The most common side effects of MUSE are penis pain, burning in the urethral opening, urethral bleeding, pain in testicles, low blood pressure, and dizziness.
Do not use MUSE if:
- Your penis is severely curved, or you have a narrow urethra, or your penis is otherwise abnormally shaped.
- The head of your penis is inflamed or you have an infection of the urethra, or regularly get infections of the urethra.
- You have sickle cell anemia or trait, any disorder of the red blood cells or platelets, multiple myeloma, or are prone to blood clots or have an abnormal thickening of the blood, because these things can mean you have an increased risk of priapism (rigid erection lasting 6 or more hours).
- You are allergic to alprostadil.
MUSE has not been studied in men who have penile implants. There is no experience in homosexual men and no experience with other than vaginal intercourse.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Patient Information.
This product is intended only for residents of the United States.
©2012 Meda Pharmaceuticals Inc. All rights reserved.
MUSE and Meda are registered trademarks of Meda AB.
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